Domino's pizza calories come to 278 for one 108 g slice of hand-tossed cheese pizza, or 257 per 100 g, based on USDA fast-food values for the chain. The number to notice is sodium: one slice carries 565 mg, 25% of the daily value, while its calories are only 14%.
278kcal
1 slice · 108 g, fast food, hand-tossed cheese
17%protein
11.7 gProtein
36 gCarbs
9.7 gFat
How to burn off 278 kcal
—Walking, brisk
—Jogging
—Cycling, moderate
—Swimming
Skip the math. BodyPal counts these calories from your steps and workouts automatically.
Nutrition facts
Fast food, hand-tossed cheese · per 108 g
Calories
278 kcal
Protein
11.7 g
Carbohydrate
36 g
Fat
9.7 g
Saturated fat
4.4 g
Cholesterol
18 mg
Sodium
565 mg
Potassium
174 mg
Iron
2.5 mg
Source: USDA FoodData Central
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Verified nutrition data
Numbers on this page come from USDA FoodData Central, the U.S. Department of Agriculture’s food composition database, and from manufacturer labels where a branded product is named. Last verified September 2026. How we verify our data →
Domino's pizza: calories, protein and sodium by serving
Percent of daily value uses the FDA reference of 2,000 kcal a day.
Serving
kcal
Protein
Carbs
Fat
Sodium
% DV kcal
1 slice (108 g)
278
11.7 g
35.9 g
9.7 g
565 mg
14%
Pepperoni slice (113 g)
308
12.7 g
36 g
12.6 g
690 mg
15%
Whole pizza (865 g)
2,223
93.4 g
287.5 g
77.6 g
4,524 mg
111%
100 g
257
10.8 g
33.2 g
9 g
523 mg
13%
3 × 1 slice (108 g)
833
35 g
1,695 mg
5 × 1 slice (108 g)
1,388
58.3 g
2,824 mg
Each slice adds about 278 calories, and the box adds up fast
A single slice of Domino's hand-tossed cheese pizza weighs 108 g and lands at 278 calories, about 14% of the daily value for energy. Few people stop at one. Two slices bring 555 calories, three slices 833, and five slices 1,388. The math is linear, so the slice count is the whole story.
The whole pizza weighs 865 g and holds 2,223 calories, which is 111% of the daily value. It also packs 93.4 g of protein and 287.5 g of carbs. Shared, it is a solid meal for a table. Eaten by one person, it is more than a full day of calories in a single sitting.
Pepperoni raises the stakes per slice. A pepperoni slice of 113 g comes in at 308 calories and 12.6 g of fat, against 278 calories and 9.7 g of fat for the cheese slice. If you are counting, log the topping, not just the slice.
Crust supplies half the calories, cheese brings real protein
Per 100 g, the cheese pizza gives 33.2 g of carbs, 10.8 g of protein and 9 g of fat. Carbs account for 52% of the calories, fat for 31% and protein for 17%. That is a crust-forward profile: the dough does most of the work, and the cheese fills in the rest.
Protein is better than pizza's reputation suggests. One slice holds 11.7 g, which is 23% of the daily value, and three slices reach 35 g. It is not a lean source, since every gram arrives with crust and fat. It is not empty food either.
Fiber stays low at 2.4 g per slice, and sugars sit at 4.3 g, much of it from the sauce and dough. Saturated fat runs 4.1 g per 100 g. Those figures look moderate one slice at a time. Across a box, they add up the same way the calories do.
Sodium is the row to watch
Sodium climbs faster than calories on this pizza. One cheese slice holds 565 mg, which is 25% of the daily value, while the same slice is only 14% of the daily calories. Per 100 g the figure is 523 mg. In other words, salt fills your daily budget well before energy does.
Two slices reach 1,130 mg and three slices 1,695 mg. Five slices hit 2,824 mg, and the whole pizza carries 4,524 mg, or 197% of the daily value. The pepperoni slice pushes harder still: 690 mg, 30% of the daily value, in a single piece.
If you watch sodium, the slice count matters more than the topping, but both count. Keep the other meals of the day lower in salt, and go easy on dipping sauces and salty sides, which add sodium on top of a number that is already high.
Two slices and a salad make a reasonable plate
Two cheese slices come to 555 calories with 23.3 g of protein, a full lunch for many adults. What the pizza lacks is fiber and volume. A side salad or a plate of raw vegetables fills that gap without adding much to the total, and it slows down the reach for a third slice.
For a pizza night, decide the slice count before the box opens. Pair the pizza with vegetables or fruit rather than wings or breadsticks, which stack more calories and sodium on top of the slices. BodyPal can log a slice from a photo, which helps when the cuts come out uneven.
These figures are USDA fast-food values for Domino's hand-tossed cheese and pepperoni pizza. Other crusts and toppings will land on different numbers, so log the closest match rather than assuming every slice is the same.
How does Domino's pizza compare?
Here is how Domino's hand-tossed cheese pizza stacks up against pepperoni pizza, cheese pizza and generic pizza, per 100 g and per usual serving.
Verdict: For the fewest calories pick Domino's hand-tossed cheese at 257 per 100 g, below generic cheese pizza at 276 and pepperoni pizza at 291. Pepperoni pizza gives slightly more protein at 12.2 g but also the most sodium at 759 mg, which makes it the weakest pick if you watch salt.
Domino's pizza FAQs
How many calories are in a slice of Domino's pizza?
A slice of 14-inch hand-tossed cheese pizza is 278 calories (108 g). A pepperoni slice is 308 calories (113 g).
How many calories are in a whole Domino's pizza?
A whole 14-inch hand-tossed cheese pizza is 2223 calories. The same pizza with pepperoni is 2476 calories.
How much protein is in a slice of Domino's pizza?
A hand-tossed cheese slice has 11.7 g protein, 9.7 g fat and 35.9 g carbs. The pepperoni slice has 12.7 g protein.
Which Domino's crust has the fewest calories?
Per slice, Crunchy Thin Crust cheese is lowest at 209 calories (70 g), hand-tossed is 278 calories (108 g) and Ultimate Deep Dish is 313 calories (118 g).
How much sodium is in a slice of Domino's pizza?
A hand-tossed cheese slice of Domino's pizza has 565 mg of sodium, 25% of the daily value. A pepperoni slice has 690 mg, or 30%. The whole pizza carries 4,524 mg.
How many calories are in two slices of Domino's pizza?
Two slices of Domino's hand-tossed cheese pizza come to 555 calories, with 23.3 g of protein and 1,130 mg of sodium. Three slices reach 833 calories.
How many calories are in a Domino's pepperoni slice?
A Domino's pepperoni slice of 113 g has 308 calories, 12.7 g of protein and 12.6 g of fat. That is about a tenth more calories than the 278-calorie cheese slice.
How many carbs are in a slice of Domino's pizza?
One slice of Domino's hand-tossed cheese pizza has 35.9 g of carbs, including 2.4 g of fiber and 4.3 g of sugars. Carbs supply 52% of the pizza's calories.
Is Domino's pizza high in fat?
A cheese slice of Domino's pizza has 9.7 g of fat, and fat supplies 31% of its calories, so it is moderate. Saturated fat is 4.1 g per 100 g, and the pepperoni slice rises to 12.6 g of fat.
